INSULIN-RESISTANCE IN ESSENTIAL-HYPERTENSION IS CHARACTERIZED BY IMPAIRED INSULIN STIMULATION OF BLOOD-FLOW IN SKELETAL-MUSCLE

Objective To determine whether insulin-stimulated blood flow in patien ts with mild essential hypertension is altered. Subjects Eleven untrea ted mildly hypertensive patients [aged 35 +/- 2 years, body mass index 25.1 +/- 0.4 kg/m(2), mean arterial pressure 110 +/- 2 mmHg (means +/ - SEM) and 10 matched normotensive subjects (mean arterial pressure 94 +/- 3 mmHg). Methods Blood flow was quantitated directly in skeletal muscle both basally and during supraphysiologic hyperinsulinemia (seru m insulin congruent to 450 mU/I) using radiowater ([O-15]H2O) and posi tron emission tomography. Whole-body and femoral muscle glucose uptake s were determined using the euglycemic insulin clamp technique, [F-18] -2-fluoro-2-deoxy-D-glucose and positron emission tomography. Results Rates of whole-body and femoral muscle glucose uptake were significant ly lower in the hypertensive than in the normotensive group. insulin i ncreased muscle blood flow by 91% in the normotensive group, but only by 33% in the hypertensive group. Conclusions The ability of insulin t o stimulate blood flow in patients with mild essential hypertension is impaired. (C) 1998 Rapid Science Ltd.