PHENOTYPIC AND GENOTYPIC ANALYSES OF BLASTIC CELL-POPULATION SUGGEST THAT PURE B-LYMPHOBLASTIC LEUKEMIA MAY ARISE FROM MYELODYSPLASTIC SYNDROME

Authors
PAJOR L MATOLCSY A VASS JA MEHES G MARTON E SZABO F IVANYI JL
Citation
L. Pajor et al., PHENOTYPIC AND GENOTYPIC ANALYSES OF BLASTIC CELL-POPULATION SUGGEST THAT PURE B-LYMPHOBLASTIC LEUKEMIA MAY ARISE FROM MYELODYSPLASTIC SYNDROME, Leukemia research, 22(1), 1998, pp. 13-17
Citations number
17
Categorie Soggetti
Oncology,Hematology
Journal title
Leukemia research → ACNP
ISSN journal
01452126
Volume
22
Issue
1
Year of publication
1998
Pages
13 - 17
Database
ISI
SICI code
0145-2126(1998)22:1<13:PAGAOB>2.0.ZU;2-K
Abstract
The case history of a 70-year-old man with myelodysplastic syndrome te rminated into acute leukemia in 22 months is presented. The leukemic c ells exhibited multifocal acid phosphatase positivity and expressed Td T, CD45, CD34 and HLA-DR but not myeloid, monocytic or megakaryocytic differentiation antigenes. The genotypic analysis revealed clonal immu noglobulin heavy chain gene rearrangement. These phenotypic and genoty pic analyses of the blastic cell population suggest that myelodysplast ic syndrome may transform to pure acute lymphoblastic leukemia of B-ce ll origin. (C) 1998 Elsevier Science Ltd. All rights reserved.