DIFFERENCES IN CD14 AND ALPHA-NAPHTHYL ACETATE ESTERASE POSITIVITY AND RELATION TO PROGNOSIS IN AML

alpha-naphthyl acetate esterase (ANAE) and CD14 expression, used for d etermination of monocytic cells, were compared and related to prognosi s in 65 AML patients. Bone marrow aspiration material from AML patient s has been used for the cytochemistry as well as flow cytometry. All n on-erythroid cells have been included in the evaluation in both method s. 17/65 cases showed at least 15% difference between the proportion C D14 and ANAE positive cells. Cases with 20% or more CD14 positivity ha d poorer prognosis. For FAB classes M0-M3, presence of 10% or more CD1 4 was negative for overall survival (P=0.01), ANAE did not show signif icant prognostic influence. (C) 1998 Elsevier Science Ltd. All rights reserved.