Stanniocalcin (STC) is a mammalian polypeptide hormone that appears to
play a role in mineral metabolism through its regulatory effects on r
enal phosphate transport. In this report we have characterized tissue-
derived STC in humans and found it to be a glycosylated, disulfide-lin
ked dimer, with similar physical and chemical properties to baculoviru
s-expressed hormone. The hormone was localized to principal and alpha-
intercalated cells in the distal half of the nephron. This is the firs
t homologous demonstration of STC proteins and cells in human tissue.
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