IMMUNOLOCALIZATION OF STANNIOCALCIN IN HUMAN KIDNEY

Stanniocalcin (STC) is a mammalian polypeptide hormone that appears to play a role in mineral metabolism through its regulatory effects on r enal phosphate transport. In this report we have characterized tissue- derived STC in humans and found it to be a glycosylated, disulfide-lin ked dimer, with similar physical and chemical properties to baculoviru s-expressed hormone. The hormone was localized to principal and alpha- intercalated cells in the distal half of the nephron. This is the firs t homologous demonstration of STC proteins and cells in human tissue. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.