STUDIES ON HYPERTHERMIA COMBINED WITH ARTERIAL BLOCKADE FOR TREATMENTOF TUMORS - (PART-I) EFFECTIVENESS OF HYPERTHERMIA COMBINED WITH ARTERIAL LIGATION

Arterial ligation was combined with hyperthermia in rabbits with VX2 t umors implanted in the leg. For seven days after arterial ligation, bl ood flow was decreased and the pH was low in both normal muscle and tu mor tissue. The temperature of normal muscle and tumor tissue increase d faster and reached a higher level on heating immediately after ligat ion than without ligation. The antitumor effect of hyperthermia was st ronger immediately after ligation than two or seven days afterwards. H owever, damage to normal muscle was severe with this combination thera py, so a better method of therapeutic arterial blockade is needed.