STUDIES ON HYPERTHERMIA COMBINED WITH ARTERIAL BLOCKADE FOR TREATMENTOF TUMORS - (PART-II) EFFECTIVENESS OF HYPERTHERMIA COMBINED WITH ARTERIAL EMBOLIZATION USING DEGRADABLE STARCH MICROSPHERES

The efficacy of temporary arterial embolization using degradable starc h microspheres combined with hyperthermia was investigated in rabbits bearing VX2 tumors. Microsphere injection caused a marked decrease of tumor blood flow and pH. During heating, there was a marked increase o f the maximum temperature in tumor tissue compared with normal muscle. Tumor growth was suppressed 330% times at 3 weeks after hyperthermia alone and 270% times following combined treatment with microspheres an d hyperthermia. Damage to normal muscle tissue was mild. In conclusion , this combination therapy may be useful for causing selective tumor d amage and reducing the effect on normal tissues.