PENETRATION OF ERYTHROCYTE-MEMBRANE BY PEROXYNITRITE - PARTICIPATION OF THE ANION-EXCHANGE PROTEIN

Participation of the anion exchange protein (Band 3 protein) of the er ythrocyte membrane in the transport of peroxynitrite into erythrocytes was shown by partial inhibition of hemoglobin oxidation by extracellu lar peroxynitrite in cells treated with Band 3 inhibitors. These resul ts demonstrate that permeation in the anionic form may be a minor path way in the membrane transport of the peroxynitrite anion/peroxynitrous acid couple, especially in membranes reach in anion exchangers or cha nnels.