ASSESSMENT OF MOTOR-ACTIVITY IN REGULATORY NEUROTOXICITY STUDIES - VALIDATION OF THE ETHOVISION VIDEO TRACKING SYSTEM IN RATS TREATED WITH AMPHETAMINE AND CHLORPROMAZINE

Authors
HEALING G HARVEY PW MCFARLANE M BUSS NAPS MALLYON BA COCKBURN A
Citation
G. Healing et al., ASSESSMENT OF MOTOR-ACTIVITY IN REGULATORY NEUROTOXICITY STUDIES - VALIDATION OF THE ETHOVISION VIDEO TRACKING SYSTEM IN RATS TREATED WITH AMPHETAMINE AND CHLORPROMAZINE, Toxicology methods, 7(4), 1997, pp. 279-287
Citations number
14
Journal title
Toxicology methods → ACNP
ISSN journal
10517235
Volume
7
Issue
4
Year of publication
1997
Pages
279 - 287
Database
ISI
SICI code
1051-7235(1997)7:4<279:AOMIRN>2.0.ZU;2-7
Abstract
A novel automated computer imaging technique for assessing motor activ ity in rats to a standard acceptable for regulatory neurotoxicity stud ies is described. The Ethovision video tracking, motion analysis, and behavior recognition system is shown to reliably assess both increases and decreases in motor activity of rats treated with D-amphetamine su lfate or chlorpromazine hydrochloride, respectively, by demonstrating statistically significant treatment-related effects with each drug. It also has advantages over existing beam-breaking systems in ease of us e and flexibility, and provides a permanent record on video tape of th e subjects examined.