WASTE-WATER REDUCTION FROM THE CULTURE-MEDIUM PREPARATION STEP OF AN ANTIBIOTIC PRODUCTION

This paper deals with the problem for waste water reduction from the c ulture medium step of an antibiotic production in a case of a heat int egrated fermentation stage. The heat integration of the fermentation s tage introduces a heat integration cycle time that decreases the time between consecutive inoculation phases of the fermenters and arises as a precondition for redistribution of the seed fermenters used in a wa y the waste water from the process to be decreased. To explore this po tential for waste reduction, a scheduling procedure for the culture me dium step is introduced involving the following main steps: determinat ion of a time horizon for the seed preparation step; creation of sched ules with a zero-release of waste water, called basic schedules and, r elaxation of the basic schedules to ensure a success of inoculation. F inally, different schedules are created for the culture medium step, a ccording to proposed procedure, and investigated from the waste reduct ion and the required pieces of equipment points of views.