COOPERATIVITY IN BINDING OF PROTEINS TO DNA - II - BINDING OF BACTERIOPHAGE-LAMBDA REPRESSOR TO THE LEFT AND RIGHT OPERATORS

In continuation of part one [J. Chem. Phys. 107, 10242 (1997)] we furt her examine the sources of ligand-ligand correlations in binding of pr oteins to DNA. We present four reasons for expecting that, in contrast to the ligand-ligand interactions, the correlations between ligands i n these systems can be long ranged and nonadditive. In view of these f indings we reexamine a specific set of experimental data on the bindin g of lambda repressor to the corresponding operators. (C) 1998 America n Institute of Physics.