We compute the elastic interaction between two identical conical inclu
sions in a spherical vesicle. We find it always repulsive and proporti
onal to the square of the contact angle. At small angular separations
Theta it decays as Theta(-4), as in the case of planar membranes. Afte
r a crossover Theta(c) similar to psi(0.54) where psi is the inclusion
s' aperture, it decays as Theta(-0.33), yielding a much stronger force
than in a flat membrane. Finally, a quadratic minimum around the anti
-polar configuration Theta = pi is reached.