USE OF VORICONAZOLE IN TREATMENT OF SCEDOSPORIUM-APIOSPERMUM INFECTION - CASE-REPORT

We report a case of disseminated Scedosporium apiospermum infection in a neutropenic patient with acute myeloid leukemia. Due to progression of the mycosis after 7 days of amphotericin B lipid complex therapy a nd to high susceptibility of the mold to voriconazole in vitro, the pa tient was treated with intravenous voriconazole, After a few days of t herapy, fever disappeared and skin lesions improved. However, the pati ent died after 1 month due to intestinal bleeding. Despite a negative outcome, this case seems to indicate a promising role for voriconazole in the treatment of S. apiospermum infections.