SYNTHESIS, EVALUATION AND TC-99M COMPLEXATION OF A HYDRAZINONICOTINYLCONJUGATE OF A GP IIB IIIA ANTAGONIST CYCLIC PEPTIDE FOR THE DETECTION OF DEEP-VEIN THROMBOSIS/

Authors
RAJOPADHYE M HARRIS TD YU K GLOWACKA D DAMPHOUSSE PR BARRETT JA HEMINWAY SJ EDWARDS DS CARROLL TR
Citation
M. Rajopadhye et al., SYNTHESIS, EVALUATION AND TC-99M COMPLEXATION OF A HYDRAZINONICOTINYLCONJUGATE OF A GP IIB IIIA ANTAGONIST CYCLIC PEPTIDE FOR THE DETECTION OF DEEP-VEIN THROMBOSIS/, Bioorganic & medicinal chemistry letters, 7(8), 1997, pp. 955-960
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
8
Year of publication
1997
Pages
955 - 960
Database
ISI
SICI code
0960-894X(1997)7:8<955:SEATCO>2.0.ZU;2-5
Abstract
A cyclic peptide GP IIb/IIIa receptor antagonist containing the N-Me A rg-Gly-Asp motif has been derivatized with the technetium chelating hy drazinonicotinyl group (Hynic). The Hynic derivative, and the Tc-99 di azenido complex, retain the high receptor affinity of the parent pepti de. The Tc-99m complex shows high thrombus uptake, and rapid clearance of background, producing excellent images in under 1 h. (C) 1997 The DuPont Merck Pharmaceutical Company.