BENZO[C]QUINOLIZINIUMS - A NEW FAMILY OF INHIBITORS FOR PROTEIN-KINASE CKII

Authors
METTEY Y VIERFOND JM BAUDRY M COCHET C SARROUILHE D
Citation
Y. Mettey et al., BENZO[C]QUINOLIZINIUMS - A NEW FAMILY OF INHIBITORS FOR PROTEIN-KINASE CKII, Bioorganic & medicinal chemistry letters, 7(8), 1997, pp. 961-964
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
8
Year of publication
1997
Pages
961 - 964
Database
ISI
SICI code
0960-894X(1997)7:8<961:B-ANFO>2.0.ZU;2-9
Abstract
A series of bicyclic enols 3 and tricyclic benzo[c]quinoliziniums 4 an d 5 were prepared. and evaluated as inhibitors of protein kinase CKII. Of the seventeen derivatives examined, 6-hydroxy-benzo[c]quinoliziniu m 5d was the most potent inhibitor and exhibited a good selectivity fo r CKII in the micromolar range. (C) 1997 Elsevier Science Ltd.