EVALUATING MOTOR END-PLATE-TARGETED INJECTIONS OF BOTULINUM TOXIN TYPE-A IN A CANINE MODEL

Tarsal joint forces were measured in dogs over 70 days following botul inum toxin type A (BTX-A) injections. Three dogs were injected at moto r end-plates located by electromyography (EMG), while 3 dogs were simi larly injected, but without EMG guidance. Extension forces were signif icantly (P < 0.05) smaller in limbs injected at motor end-plates than in corresponding limbs an days 14 and 35, There were no significant di fferences at other times. Using these techniques, EMG end-plate target ing potentiates effects of BTX-A, (C) 1998 John Wiley & Sons, Inc.