MU-OPIOID RECEPTOR KNOCKOUT IN MICE - EFFECTS ON LIGAND-INDUCED ANALGESIA AND MORPHINE LETHALITY

Authors
LOH HH LIU HC CAVALLI A YANG WL CHEN YF WEI LN
Citation
Hh. Loh et al., MU-OPIOID RECEPTOR KNOCKOUT IN MICE - EFFECTS ON LIGAND-INDUCED ANALGESIA AND MORPHINE LETHALITY, Molecular brain research, 54(2), 1998, pp. 321-326
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
54
Issue
2
Year of publication
1998
Pages
321 - 326
Database
ISI
SICI code
0169-328X(1998)54:2<321:MRKIM->2.0.ZU;2-6
Abstract
The mu opioid receptor gene (MOR) was mutated in mice by a gene target ing procedure. In these MOR-knockout mice, the analgesic effects of mo rphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morp hine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphin e-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic ef fects of mu-specific opioid ligands and acute morphine lethality are m ediated by the mu receptor. (C) 1998 Elsevier Science B.V.