STRUCTURE-BASED DESIGN OF NOVEL CALCINEURIN (PP2B) INHIBITORS

Authors
TATLOCK JH LINTON MA HOU XJ KISSINGER CR PELLETIER LA SHOWALTER RE TEMPCZYK A VILLAFRANCA JE
Citation
Jh. Tatlock et al., STRUCTURE-BASED DESIGN OF NOVEL CALCINEURIN (PP2B) INHIBITORS, Bioorganic & medicinal chemistry letters, 7(8), 1997, pp. 1007-1012
Citations number
49
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
8
Year of publication
1997
Pages
1007 - 1012
Database
ISI
SICI code
0960-894X(1997)7:8<1007:SDONC(>2.0.ZU;2-1
Abstract
The design, synthesis, and evaluation of small molecule, in vitro, inh ibitors of human calcineurin is described. These ligands were derived from the known nonspecific phosphatase inhibitor endothall, and were m odified to enhance binding and selectivity toward calcineurin using pr otein crystal structure information. (C) 1997 Elsevier Science Ltd.