AUTOMATED SOLID-PHASE ORGANIC-SYNTHESIS IN MICRO-PLATE WELLS - SYNTHESIS OF N-(ALKOXY-ACYL)AMINO ALCOHOLS

Authors
KRCHNAK V WEICHSEL AS LEBL M FELDER S
Citation
V. Krchnak et al., AUTOMATED SOLID-PHASE ORGANIC-SYNTHESIS IN MICRO-PLATE WELLS - SYNTHESIS OF N-(ALKOXY-ACYL)AMINO ALCOHOLS, Bioorganic & medicinal chemistry letters, 7(8), 1997, pp. 1013-1016
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
8
Year of publication
1997
Pages
1013 - 1016
Database
ISI
SICI code
0960-894X(1997)7:8<1013:ASOIMW>2.0.ZU;2-T
Abstract
The technique of concurrent solid-phase organic synthesis in 96-deep-w ell micro-titer plates is outlined and documented with the synthesis o f N-(alkoxy-acyl)amino alcohols. Typically resin beads are separated f rom solvent using filtration approach that complicates automation. Ins tead we describe a method employing settling of resin, followed by asp iration of supernatant. (C) 1997 Elsevier Science Ltd.