SYNTHESIS AND BINDING-AFFINITY OF NEW MUSCARINIC LIGANDS STRUCTURALLYRELATED TO OXOTREMORINE

Authors
CONTI P DALLANOCE C DEAMICI M DEMICHELI C EBERT B
Citation
P. Conti et al., SYNTHESIS AND BINDING-AFFINITY OF NEW MUSCARINIC LIGANDS STRUCTURALLYRELATED TO OXOTREMORINE, Bioorganic & medicinal chemistry letters, 7(8), 1997, pp. 1033-1036
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
8
Year of publication
1997
Pages
1033 - 1036
Database
ISI
SICI code
0960-894X(1997)7:8<1033:SABONM>2.0.ZU;2-9
Abstract
The synthesis and radioligand binding assays of a group of muscarinic ligands related to oxotremorine are reported. The new compounds displa yed binding affinities comparable to those of the parent molecule with the exception of the trimethylammonium salt 6, which behaved as a fil l muscarinic agonist and showed a pronounced selectivity for M-2 versu s M-1 muscarinic receptor subtypes. (C) 1997 Elsevier Science Ltd.