ECD PEPTIDES INHIBIT IN-VITRO FERTILIZATION IN MICE

Authors
PYLUCK A YUAN RY GALLIGAN E PRIMAKOFF P MYLES DG SAMPSON NS
Citation
A. Pyluck et al., ECD PEPTIDES INHIBIT IN-VITRO FERTILIZATION IN MICE, Bioorganic & medicinal chemistry letters, 7(8), 1997, pp. 1053-1058
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
8
Year of publication
1997
Pages
1053 - 1058
Database
ISI
SICI code
0960-894X(1997)7:8<1053:EPIIFI>2.0.ZU;2-3
Abstract
Cyclic and linear peptides containing the conserved ECD sequence from the disintegrin domain of the beta-subunit of fertilin were synthesize d and tested as inhibitors of sperm-egg fusion in in vitro mouse ferti lization assays. At 500 mu M concentrations, reduced ECD peptides inhi bited fertilization, whereas oxidized dimers did not. Control peptides suggest that more than three amino acids of the disintegrin domain ar e recognized by its receptor. (C) 1997 Elsevier Science Ltd.