GLUCURONIDE PRODRUGS OF HYDROXY COMPOUNDS FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) - A PHENOL NITROGEN-MUSTARD CARBAMATE

Authors
SCHMIDT F FLORENT JC MONNERET C STRAUB R CZECH J GERKEN M BOSSLET K
Citation
F. Schmidt et al., GLUCURONIDE PRODRUGS OF HYDROXY COMPOUNDS FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) - A PHENOL NITROGEN-MUSTARD CARBAMATE, Bioorganic & medicinal chemistry letters, 7(8), 1997, pp. 1071-1076
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
8
Year of publication
1997
Pages
1071 - 1076
Database
ISI
SICI code
0960-894X(1997)7:8<1071:GPOHCF>2.0.ZU;2-6
Abstract
A prodrug consisting of a beta-D-glucuronic acid linked to a self-immo lative spacer (a N-(orthohydroxyphenyl)-N-methylcarbamate) and a pheno lic nitrogen mustard was synthesised. As this prodrug was easily cleav ed by a beta-glucuronidase enzyme and displayed low cytotoxicity, it m ust be considered as appropriate for an ADEPT approach. (C) 1997 Elsev ier Science Ltd.