The initial fixation properties of bioresorbable polylactic acid (PLA)
interference screws designed for anterior cruciate ligament reconstru
ction were evaluated using an in vitro bovine model. The surgical tech
nique of interference screw fixation of the bone-patellar tendon-bone
autograft complex performed clinically was reproduced in an adult bovi
ne model. The reconstructed knee was tested oriented in 30 degrees of
flexion to allow examination of the femoral and tibial fixation proper
ties simultaneously. This model examined the initial fixation strength
between PLA and metal interference screws as well as a partially degr
aded PLA implant. Data from this in vitro model indicate that PLA inte
rference screws can provide similar initial fixation at both time 0 an
d after degradation for up to 28 days compared with metal interference
screws for bone-tendon-bane ACL reconstructions.