A FAMILY-BASED ANALYSIS OF THE ASSOCIATION OF THE DOPAMINE D2 RECEPTOR (DRD2) WITH ALCOHOLISM

The possible association of the DRD2 locus, and in particular the Taql -A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations, To avoid problems associated with differences in allele frequencies in different popula tions, we tested whether the DRD2 locus is associated with alcohol dep endence in a large family-based sample. Neither the transmission/diseq uilibrium test nor the Affected Family-Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence.