COMPLETE REMISSION OF BRAIN METASTASES FROM OVARIAN-CARCINOMA WITH CARBOPLATIN

Central nervous system involvement by epithelial ovarian carcinoma is rare. We report the case of a 49 year old woman with stage IV serous c arcinoma of the ovary who developed multiple cerebral and cerebellar m etastases 7 months after achieving complete response to platin-based c hemotherapy. Eight courses of carboplatin (400 mg/m(2)) were administe red and after the second cycle complete remission of the brain deposit s occured. The treatment afforded rapid subjective and objective relie f and was associated with a good quality of life. Abdominal recurrent disease was diagnosed 22 months after treatment for brain involvement. Paltin-based chemotherapy was reinstated, but the patient died from p rogressive adbominal disease without any sign of cerebral involvement and any neurological symptomatology. Carboplatin should be considered for the treatment of ovarian carcinoma metastatic to the brain. (C) 19 98 Elsevier Science Ireland Ltd.