ALLOSTERIC EFFECTS OF DNA ON TRANSCRIPTIONAL REGULATORS

Authors
LEFSTIN JA YAMAMOTO KR
Citation
Ja. Lefstin et Kr. Yamamoto, ALLOSTERIC EFFECTS OF DNA ON TRANSCRIPTIONAL REGULATORS, Nature, 392(6679), 1998, pp. 885-888
Citations number
66
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Nature → ACNP
ISSN journal
00280836
Volume
392
Issue
6679
Year of publication
1998
Pages
885 - 888
Database
ISI
SICI code
0028-0836(1998)392:6679<885:AEODOT>2.0.ZU;2-J
Abstract
Selective gene transcription is mediated in part by regulatory protein s that bind to DNA response elements. These regulatory proteins receiv e global information from signal-transduction events. But transcriptio nal regulators may also be modified in an allosteric manner by respons e elements themselves to generate the pattern of regulation that is ap propriate to an individual gene.