PROTECTION OF THE C(7) AND C(10) HYDROXYL-GROUPS IN 10-DEACETYL BACCATIN-III

Authors
HOLTON RA ZHANG ZM CLARKE PA NADIZADEH H PROCTER DJ
Citation
Ra. Holton et al., PROTECTION OF THE C(7) AND C(10) HYDROXYL-GROUPS IN 10-DEACETYL BACCATIN-III, Tetrahedron letters, 39(19), 1998, pp. 2883-2886
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
19
Year of publication
1998
Pages
2883 - 2886
Database
ISI
SICI code
0040-4039(1998)39:19<2883:POTCAC>2.0.ZU;2-6
Abstract
New protocols for the selective protection of the C(7) and C(10) hydro xyl groups of 10-deacetyl baccatin III are described, leading to more efficient semisyntheses of taxol and taxol analogs. The C(10) hydroxyl group of 10-DAB can be highly selectively acylated or silylated, and subsequent selective protection of the C(7) hydroxyl group then become s straightforward. (C) 1998 Elsevier Science Ltd. All rights reserved.