SYNTHESIS OF THE C1-C9 CORE OF BENGAZOLE-A - HARNESSING THE AMBIDENT NUCLEOPHILICITY OF 2-LITHIOOXAZOLE

Authors
SHAFER CM MOLINSKI TF
Citation
Cm. Shafer et Tf. Molinski, SYNTHESIS OF THE C1-C9 CORE OF BENGAZOLE-A - HARNESSING THE AMBIDENT NUCLEOPHILICITY OF 2-LITHIOOXAZOLE, Tetrahedron letters, 39(19), 1998, pp. 2903-2906
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
19
Year of publication
1998
Pages
2903 - 2906
Database
ISI
SICI code
0040-4039(1998)39:19<2903:SOTCCO>2.0.ZU;2-P
Abstract
An advanced intermediate for the synthesis of bengazole A (I) was prep ared by direct grafting of oxazole to a protected side-chain synthon ( prepared from D-galactose) through C-l-directed addition (oxazole numb ering) to the ambident nucleophile, 2-lithiooxazole. (C) 1998 Elsevier Science Ltd. All rights reserved.