SYNTHESIS OF FLUORESCENT PHOSPHATIDYLINOSITOLS USING A NOVEL INOSITOLH-PHOSPHONATE

Authors
LEUNG LW VILCHEZE C BITTMAN R
Citation
Lw. Leung et al., SYNTHESIS OF FLUORESCENT PHOSPHATIDYLINOSITOLS USING A NOVEL INOSITOLH-PHOSPHONATE, Tetrahedron letters, 39(19), 1998, pp. 2921-2924
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
19
Year of publication
1998
Pages
2921 - 2924
Database
ISI
SICI code
0040-4039(1998)39:19<2921:SOFPUA>2.0.ZU;2-K
Abstract
Coupling of 1,2-diradyl-sn-glycerol 5 with the novel inositol H-phosph onate derivative, -O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inositol H -phosphonate (3), gave fluorescent analogs of phosphatidylinositol (Pt dIns, 1) and PtdIns(4,5)-bisphosphate (PtdIns(4,5)P-2, 2). Unlike the corresponding phosphoramidate, 3 was stable at -20 degrees C for sever al months, making it a useful intermediate for the synthesis of myo-in ositol phospholipids. (C) 1998 Elsevier Science Ltd. All rights reserv ed.