ARTEMISININ TRICYCLIC ANALOGS - ROLE OF A METHYL-GROUP AT C-5A

Authors
ZOUHIRI F DESMAELE D DANGELO J RICHE C GAY F CICERON L
Citation
F. Zouhiri et al., ARTEMISININ TRICYCLIC ANALOGS - ROLE OF A METHYL-GROUP AT C-5A, Tetrahedron letters, 39(19), 1998, pp. 2969-2972
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
19
Year of publication
1998
Pages
2969 - 2972
Database
ISI
SICI code
0040-4039(1998)39:19<2969:ATA-RO>2.0.ZU;2-A
Abstract
New artemisinin tricyclic analogs, bearing a methyl group at C-5a were synthetized through ozonation of vinylsilanes. Presence of such a sub stituent was detrimental to the antimalarial activity of these trioxan es, thus reinforcing the hypothesis that tight hemin-trioxane complexe s are involved in the activation phase of these compounds. (C) 1998 El sevier Science Ltd. All rights reserved.