VIRILIZING OVARIAN TUMOR OF LOW MALIGNANT POTENTIAL ASSOCIATED WITH ANTECEDENT TAMOXIFEN USE FOR BREAST-CANCER

A patient is described who was treated with tamoxifen for breast cance r and developed an androgen-producing ovarian tumor of low malignant p otential, which itself is a rare condition. Clinically overt virilism was leading to the diagnosis and promptly improved after surgical remo val of the tumor. A causal relationship between tamoxifen use and the tumor is discussed on the basis of the known tumor-inducing potential of tamoxifen. (C) 1998 Academic Press.