REDUCED MEAL RELATED GASTROINTESTINAL HORMONE RESPONSE TO ADRENOCORTICOTROPIC HORMONE STIMULATION TEST IN FEMALE ATHLETES

Citation
Al. Hirschberg et al., REDUCED MEAL RELATED GASTROINTESTINAL HORMONE RESPONSE TO ADRENOCORTICOTROPIC HORMONE STIMULATION TEST IN FEMALE ATHLETES, Gynecological endocrinology, 11(2), 1997, pp. 83-89
Citations number
24
Categorie Soggetti
Endocrynology & Metabolism","Obsetric & Gynecology
Journal title
ISSN journal
09513590
Volume
11
Issue
2
Year of publication
1997
Pages
83 - 89
Database
ISI
SICI code
0951-3590(1997)11:2<83:RMRGHR>2.0.ZU;2-W
Abstract
This study was undertaken to elucidate the impact of hypercortisolism in meal-related gastrointestinal hormone secretion and appetite in fem ale endurance athletes. Thirteen elite runners and seven sedentary wom en participated on two occasions, either receiving intravenous injecti on of 250 mu g synthetic adrenocorticotropic hormone (ACTH) 1-24 or sa line. Blood samples were collected before and after tile injection, an d then in connection with a standardized meal. Serum concentrations of cortisol, cholecystokinin (CCK), gastrin, insulin and glucose were an alyzed. Self-ratings of appetite were assessed by visual analog scales . Elevated basal levels of cortisol and glucose were found in the athl etes. ACTH-induced cortisol response was comparable between groups, bu t a negative correlation between basal cortisol levels and the ACTH-in duced response was found. In sedentary women, ACTH challenge enhanced meal-related CCK and gastrin responses, whereas athletes showed a blun ted response of these hormones combined with decreased satiety and red uced levels of insulin. Blunted meal-related response of gastrointesti nal hormones and decreased satiety in female runners after ACTH stimul ation compared to sedentary women are probably due to differences in t he effect of cortisol, which could be explained by cortisol insensitiv ity as a result of basal hypercortisolism in the athletes. Decreased C CK response and satiety in female athletes may reflect increased nutri tional requirements.