ROLE OF FAS LIGAND (CD95L) IN IMMUNE ESCAPE - THE TUMOR-CELL STRIKES BACK - COMMENTARY

Several different tumor types have recently been shown to express func tional Fas ligand (Fast), which may represent an additional mechanism of tumor escape. However, the in vivo significance of these findings i n the context of potent adversaries such as activated CTL or NK cells remains to be fully established, The potential interactions between tu mor cells and the host immune response are thus more complex than prev iously thought; their elucidation will benefit the rational design of cancer immunotherapy strategies.