Object. The aim of this study was to investigate the indications and t
reatment options in patients with lower-extremity neuropathies and rad
iculopathies caused by endometriosis. Methods. The authors identified
five patients whose symptoms included catamenial pain, weakness, and s
ensory loss involving the sciatic and femoral nerves and multiple lumb
osacral nerve roots. Radiographic studies supported the diagnosis of c
atamenial neuropathy or radiculopathy, but definitive diagnosis depend
ed on surgical and pathological examination. Treatment of symptoms, in
cluding physical therapy and a course of antiinflammatory or analgesic
medication, was not helpful. Patients responded favorably to hormonal
therapy. Laparoscopy or open exploration for extrapelvic lesions was
performed for diagnosis or for treatment when hormone therapy failed.
Pain and sensory symptoms responded well to therapy. Weakness improved
, but never recovered completely. Conclusions. Catamenial neuropathy o
r radiculopathy should be considered when evaluating reproductive-age
women with recurring focal neuropathic leg pain, weakness, and sensory
loss.