SELECTIVE INTRAARTERIAL GENE DELIVERY INTO A CANINE MENINGIOMA

Object. The goal of this study was to evaluate gene delivery to a beni gn brain tumor. Methods. A recombinant adenovirus vector bearing the E scherichia coli beta-galactosidase reporter gene was selectively injec ted into the vascular supply of a spontaneously occurring canine olfac tory groove meningioma. The tumor and a small amount of peritumoral br ain tissue were removed 5 days after viral injection and stained with X-Gal to assess gene delivery. The authors noted significant beta-gala ctosidase gene expression by the tumor, but not by surrounding brain t issue. No obvious viral-related cytotoxicity was noted. Conclusions. T he authors found that meningiomas can be successfully transduced by ad enovirus vectors By using endovascular techniques.