NUMERICAL-SIMULATION FOR CAPILLARY ELECTROPHORESIS I - DEVELOPMENT OFA SIMULATION PROGRAM WITH HIGH NUMERICAL STABILITY

A computer program was developed for the simulations of capillary elec trophoresis on the basis of unsteady partial differential equations. S ince a new algorithm (shifted upwinding approximation) was used to sup press numerical divergence and oscillation, the program succeeded in g enerating only physically meaningful peaks at the cost of slight overe stimation of ionic diffusion. The mathematical model and equations use d in the program were described in detail, and simulation performance was compared among the previously reported programs, confirming the nu merical stability of our program. As an application example, a system peak in indirect UV detection was simulated. (C) 1998 Published by Els evier Science B.V.