INTERPLAY OF MATRICES IN CARTILAGE SYNOVIAL-FLUID COMBINE UNDER MODERATE AND HIGH LOADINGS

Interplay of the constituents of the articular cartilage synovial flui d combine and its role was examined through the biochemical and rheolo gical studies on bovine joints. The results showed an inverse relation ship between the changes in the hyaluronic acid of synovial fluid and the proteoglycans content in articular cartilage together with alterat ions in the rheological properties of synovial fluid. The study indica ted that the inter-movement of fluid solutes across the cartilage and synovial fluid may have an important role in the pathophysiology of os teoarthritis.