We describe a 61-year-old male patient who was treated with allopurino
l and developed fever, a skin rash, eosinophilia and severe renal and
liver dysfunction. We discuss the allopurinol hypersensitivity syndrom
e as a serious complication of the use of allopurinol, and briefly rev
iew the aetiology, prevention and treatment modalities. (C) 1998 Elsev
ier Science B.V.