A METHOD FOR CREATING REVERSIBLE URETERAL OBSTRUCTION IN THE PRIMATE

A technique has been developed for the establishment of a state of rev ersible, ureteric obstruction in the primate. Ten adult males had base line Tc-99m-DTPA renogram studies. A randomly selected ureter was tota lly occluded and obstruction confirmed on renogram. The occlusion was reversed and subsequent renograms confirmed recovery of activity in th e obstructed kidneys of the eight animals who survived the reversal pr ocedure. Seven were alive on conclusion of the study. Prevention of ur eteric strictures was achieved with an intra-ureteric silastic tube. A utopsies demonstrated patency of every previously occluded ureter. Thi s is the first study to be reported in primates, and the second overal l, in which complete ureteric obstruction and its successful reversal has been confirmed on renogram using this surgical method. The techniq ue is suitable for the study of the effect of reversible ureteric obst ruction on renal function.