RECURRENT STREPTOCOCCUS-PNEUMONIAE SEPSIS IN CHILDREN WITH SICKLE-CELL DISEASE

Streptococcus pneumoniae sepsis is the most common invasive infection among patients with sickle cell disease. The risk of a recurrent episo de of sepsis and subsequent death in those patients who have had a pre vious septic event is much higher. Patients with sickle disease who ha ve had pneumococcal sepsis should continue penicillin prophylaxis inde finitely and should not be candidates for out-patient patient manageme nt of febrile episodes.