ANTIVIRAL EFFECT ON TRIMERIC 2',5'-OLIGOADENYLIC ACID AND SOME OF ITSANALOGS

Authors
TKACHUK ZY SEMERNIKOVA LI TKACHUK VV RESHOTKO LM TRACHUK LV EREMENKO T MATSUKA GKH MIKHAILOPULO IA
Citation
Zy. Tkachuk et al., ANTIVIRAL EFFECT ON TRIMERIC 2',5'-OLIGOADENYLIC ACID AND SOME OF ITSANALOGS, The New microbiologica, 21(2), 1998, pp. 141-146
Citations number
11
Categorie Soggetti
Microbiology
Journal title
The New microbiologica
ISSN journal
11217138 → ACNP
Volume
21
Issue
2
Year of publication
1998
Pages
141 - 146
Database
ISI
SICI code
1121-7138(1998)21:2<141:AEOT2A>2.0.ZU;2-Y
Abstract
The antiviral effect of 2',5'-trioligoadenylate (2',5'-A(3)) and some of its analogues was studied using several model cell culture systems and viruses: mice L929 fibroblast cells inoculated with vaccine virus, testicular piglet cells inoculated with Aueszki disease virus (strain BUK-628), and the same culture inoculated with a reference strain of transmissible.gastroenteritis virus, strain Purdue - 115. Our results suggest that both 2',5'-trioligoadenylate and its analogues are promis ing antiviral substances against DNA-and RNA-containing viruses.