THE EFFECT OF TRIMERIC 2',5'-OLIGOADENYLIC ACID AND ITS EPOXY-DERIVATIVE ON HUMAN-IMMUNODEFICIENCY-VIRUS (HIV-1) REPRODUCTION AND RETROVIRUSES REVERSE-TRANSCRIPTASE ACTIVITY

Authors
TKACHUK ZY RYBALKO SL SEMERNIKOVA LI TKACHUK VV ZAVELEVICH MP TKACHUK LV EREMENKO T MIKHAILOPULO IA MATSUKA GKH
Citation
Zy. Tkachuk et al., THE EFFECT OF TRIMERIC 2',5'-OLIGOADENYLIC ACID AND ITS EPOXY-DERIVATIVE ON HUMAN-IMMUNODEFICIENCY-VIRUS (HIV-1) REPRODUCTION AND RETROVIRUSES REVERSE-TRANSCRIPTASE ACTIVITY, The New microbiologica, 21(2), 1998, pp. 197-201
Citations number
12
Categorie Soggetti
Microbiology
Journal title
The New microbiologica
ISSN journal
11217138 → ACNP
Volume
21
Issue
2
Year of publication
1998
Pages
197 - 201
Database
ISI
SICI code
1121-7138(1998)21:2<197:TEOT2A>2.0.ZU;2-V
Abstract
The effect of trimeric 2',5'-oligoadenylic acid (2',5'A(3)) and its ep oxy-derivative (2',5'-A(2)((RA)A) on human immunodeficiency virus (HIV -1) reproduction was studied. An HIV-1 infectivity titer decrease was shown on the model of limphoblastoid cells when the substances under s tudy were used. The interferonogenic effect of both substances was dis covered. 2',5'-A(2)((RA)A) inhibited the activity of retrovirus revers e transcriptase (a C-type).