ALUMINUM DECREASES THE MAGNESIUM CONCENTRATION OF SPINAL-CORD AND TRABECULAR BONE IN RATS FED A LOW-CALCIUM, HIGH ALUMINUM DIET

Authors
Citation
M. Yasui et K. Ota, ALUMINUM DECREASES THE MAGNESIUM CONCENTRATION OF SPINAL-CORD AND TRABECULAR BONE IN RATS FED A LOW-CALCIUM, HIGH ALUMINUM DIET, Journal of the neurological sciences, 157(1), 1998, pp. 37-41
Citations number
36
Categorie Soggetti
Neurosciences
ISSN journal
0022510X
Volume
157
Issue
1
Year of publication
1998
Pages
37 - 41
Database
ISI
SICI code
0022-510X(1998)157:1<37:ADTMCO>2.0.ZU;2-0
Abstract
Current epidemiological surveys in the Western Pacific (Guam, and Kii Peninsula and West New Guinea) have suggested that low calcium (Ca), m agnesium (Mg) and high aluminum (Al) and manganese (Mn) in river, soil and drinking water may be implicated in the pathogenetic process of f oci of amyotrophic lateral sclerosis GALS) and parkinsonism-dementia ( PD). The condition of unbalanced minerals was experimentally mimicked in this study using rats. Male Wistar rats, weighing 200 g, were maint ained for 60 days on the following diets: (A) standard diet, (B) low C a diet, (C) low Ca diet plus high Al. Magnesium concentrations were de termined in spinal cord and trabecular bone using inductively coupled plasma emission spectrometry (ICP). In the experimental group maintain ed on a low Ca, high Al diet, magnesium concentration of the spinal co rd was lower than the group fed a standard diet. Also, magnesium conce ntration of lumbar vertebra showed lower values in the experimental gr oup fed a low Ca, high Al diet than did those on a standard diet or lo w Ca diet without supplemental aluminum. Our data indicate that low Ca , high Al diet influences Mg concentration in bone and central nervous system (CNS) tissues and that a low Ca, high Al diet diminishes Mg in bone and CNS tissues, thereby inducing loss of calcification in bone and degeneration of CNS tissue due to alteration of the normal biologi cal effects of Mg. (C) 1998 Elsevier Science B.V.