Y. Tagawa et al., ABILITY TO REMOVE IMMUNOGLOBULINS AND ANTIGANGLIOSIDE ANTIBODIES BY PLASMA-EXCHANGE, DOUBLE-FILTRATION PLASMAPHERESIS AND IMMUNOADSORPTION, Journal of the neurological sciences, 157(1), 1998, pp. 90-95
In Japan, patients with Guillain-Barre (GBS) and Fisher's (FS) syndrom
es often receive plasma exchange (PE), double-filtration plasmapheresi
s (DFPP). or immunoadsorption (IA). To determine whether DFPP and IA a
re as effective as PE, we compared their abilities to remove immunoglo
bulins and anti-ganglioside antibodies. Plasma samples were obtained f
rom 55 GBS patients and 53 FS patients, before and after each session
of the treatments. PE decreased the IgG concentration more than DFPP d
id, its abilities to remove anti-ganglioside IgG antibodies in PE mark
edly being superior to the abilities of the other plasmaphereses. IA o
n a tryptophan-immobilized column adsorbed anti-ganglioside IgG antibo
dies more effectively than IA on other affinity columns. (C) 1998 Else
vier Science B.V.