E. Salloum et al., HYPERLEUKOCYTOSIS AND RETINAL HEMORRHAGES AFTER CHEMOTHERAPY AND FILGRASTIM ADMINISTRATION FOR PERIPHERAL-BLOOD PROGENITOR-CELL MOBILIZATION, Bone marrow transplantation, 21(8), 1998, pp. 835-837
A 49-year-old man with mantle cell lymphoma received 2.5 g/m(2) of cyc
lophosphamide and 900 mg/m(2) of etoposide followed by 10 mu g/kg/day
of Filgrastin for PBPC mobilization. This was complicated by marked hy
perleukocytosis and retinal hemorrhages, The patient's symptoms improv
ed gradually following leukopheresis. To the best of our knowledge, th
is is the first report describing this complication in patients underg
oing PBPC mobilization. Early recognition of symptoms is important in
order to stop Filgrastim and initiate immediate leukapheresis.