HYPERLEUKOCYTOSIS AND RETINAL HEMORRHAGES AFTER CHEMOTHERAPY AND FILGRASTIM ADMINISTRATION FOR PERIPHERAL-BLOOD PROGENITOR-CELL MOBILIZATION

Authors
SALLOUM E STOESSEL KM COOPER DL
Citation
E. Salloum et al., HYPERLEUKOCYTOSIS AND RETINAL HEMORRHAGES AFTER CHEMOTHERAPY AND FILGRASTIM ADMINISTRATION FOR PERIPHERAL-BLOOD PROGENITOR-CELL MOBILIZATION, Bone marrow transplantation, 21(8), 1998, pp. 835-837
Citations number
11
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
21
Issue
8
Year of publication
1998
Pages
835 - 837
Database
ISI
SICI code
0268-3369(1998)21:8<835:HARHAC>2.0.ZU;2-H
Abstract
A 49-year-old man with mantle cell lymphoma received 2.5 g/m(2) of cyc lophosphamide and 900 mg/m(2) of etoposide followed by 10 mu g/kg/day of Filgrastin for PBPC mobilization. This was complicated by marked hy perleukocytosis and retinal hemorrhages, The patient's symptoms improv ed gradually following leukopheresis. To the best of our knowledge, th is is the first report describing this complication in patients underg oing PBPC mobilization. Early recognition of symptoms is important in order to stop Filgrastim and initiate immediate leukapheresis.