A 50-year-old diabetic man developed necrotizing scleritis with adjace
nt keratitis 4 weeks after uncomplicated cataract extraction and intra
ocular lens implantation through a scleral tunnel incision. Cultures o
f the necrotic sclera grew Rhizopus species. Severe destruction of the
globe ensued despite topical, subconjunctival, and intravenous amphot
ericin B, in combination with hyperbaric oxygen therapy. Histopatholog
ical examination of the enucleated globe was consistent with Rhizopus
infection. One year later, the patient was well without signs fo recur
rence.