Em. Yoshida et al., LATE RECURRENT POSTTRANSPLANT PRIMARY BILIARY-CIRRHOSIS IN BRITISH-COLUMBIA, Canadian journal of gastroenterology, 11(3), 1997, pp. 229-233
Late recurrent primary biliary cirrhosis (PBC) following orthotopic li
ver transplant remains a controversial topic. The first documented cas
e of recurrence occurring in 16 patients transplanted for PBC and foll
owed at the authors' institution for longer than one year is presented
. A 54-year-old man transplanted for PBC developed a cholestatic patte
rn of enzyme elevation on pose-transplant day (PTD) 1305. Repeat antim
itochondrial antibody was strongly positive (1:300 to 1:400). A liver
biopsy revealed severe bile duct damage, lymphocytic cholangitis, foca
l periductal noncaseating granuloma and minimal endotheliitis. Recurre
nt PBC was diagnosed. At the time of orthotopic liver transplant this
patient received induction immunosuppression with OKT3 crossed over to
cyclosporine (CsA), azathioprine (AZA) and prednisone. AZA was discon
tinued early and maintenance CsA tapered to a target trough level of 1
50 to 200 ng/mL by PTD 365. Prednisone was withdrawn by PTD 664. CsA l
evels during PTDs 1225 to 1305 (before elevation of hepatobiliary enzy
mes) were below target at 114 to 166 ng/mL. Of the 16 patients, all bu
t three were maintained on CsA, AZA and prednisone. One was on CsA (tr
ough levels on target) and AZA; the other two, including the patient w
ith recurrent PBC, were on CsA only. The trough CsA level of the patie
nt without recurrent PBC has been within the-target range. The authors
speculate that the underlying defect in immunoregulation in PBC persi
sts post-transplant and that in the patient without recurrent PBC this
-defect was unmasked by lowered maintenance immunosuppression - allowi
ng recurrence of PBC in a previously stable liver allograft.