PREVALENCE OF BOVINE VIRAL DIARRHEA VIRUS GENOTYPES AND ANTIBODY AGAINST THOSE VIRAL GENOTYPES IN FETAL BOVINE SERUM

One thousand lots of pooled fetal bovine serum (FBS) were tested for c ontamination with bovine viral diarrhea virus (BVDV) and/or for contam ination with neutralizing antibody against BVDV. Noncytopathic or cyto pathic BVDV was isolated from 203 lots of FBS. Analysis of the viral i solates identified 115 type 1 and 65 type 2 BVDV isolates. An addition al 23 virus isolates were mixtures of greater than or equal to 2 BVDV isolates and were not classified to viral genotype. Further characteri zation of the type 1 viruses identified 51 subgenotype la and 64 subge notype Ib BVDV isolates. Viral neutralizing antibody was detected in 1 13 lots of FBS. Differential viral neutralization indicated that type 1 BVDV induced the antibody detected in 48 lots of FBS and type 2 BVDV induced the antibody detected In 16 lots of FBS.