GENERATION OF A LIBRARY OF 4-THIAZOLIDINONES UTILIZING POLYMER-SUPPORTED QUENCH (PSQ) REAGENT METHODOLOGY

Authors
AULTJUSTUS SE HODGES JC WILSON MW
Citation
Se. Aultjustus et al., GENERATION OF A LIBRARY OF 4-THIAZOLIDINONES UTILIZING POLYMER-SUPPORTED QUENCH (PSQ) REAGENT METHODOLOGY, Biotechnology and bioengineering, 61(1), 1998, pp. 17-22
Citations number
22
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology and bioengineering → ACNP
ISSN journal
00063592
Volume
61
Issue
1
Year of publication
1998
Pages
17 - 22
Database
ISI
SICI code
0006-3592(1998)61:1<17:GOALO4>2.0.ZU;2-H
Abstract
A one-pot, three-component, solution-phase synthesis of 2,3-disubstitu ted and 2,3,5-trisubstituted 4-thiazolidinones is described. Poly(styr ene-co-divinylbenzene)-supports functionalized with tris(2-aminoethyl) amine and 2-amino-ethanethiol are used to remove excess reagents from the desired product upon completion of the reaction. Simple filtration followed by concentration provides products of sufficient purity for biological evaluation. This approach has been used for a parallel comb inatorial generation of a library of multisubstituted 4-thiazolidinone s. (C) 1998 John Wiley & Sons, Inc.