PATENTS IN COMBI-SPACE - PATENT CHALLENGES IN COMBINATORIAL CHEMISTRY

Patent protection of inventions relating to combinatorial chemistry is attended by special challenges. The ''breakthrough'' nature of the fi eld together with the always complex and often arcane chemical manipul ations, apparatus, and strategies which suffuse this field make it dif ficult to describe the inventions adequately. It can be a challenge to communicate effectively with official authorities charged with patent examination. Extraordinary effort is called for in clarifying such in ventions such that their patentability can be appreciated. The utility of some types of inventions in this field may be open to question; cl ear statements of at least one acceptable utility-even if only a minor utility-is beneficial. Because a principal product of many aspects of combinatorial chemistry is information, e.g., the identification of a lead compound, offshore ''piracy'' is a risk. Domestic claim tie-ins may improve the ability to abate such piracy. (C) 1998 John Wiley & So ns, Inc.