TESTING CAUSAL HYPOTHESES IN MULTIVARIATE LINKAGE ANALYSIS OF QUANTITATIVE TRAITS - GENERAL FORMULATION AND APPLICATION TO SIBPAIR DATA

Authors
TODOROV AA VOGLER GP GU C PROVINCE MA LI Z HEATH AC RAO DC
Citation
Aa. Todorov et al., TESTING CAUSAL HYPOTHESES IN MULTIVARIATE LINKAGE ANALYSIS OF QUANTITATIVE TRAITS - GENERAL FORMULATION AND APPLICATION TO SIBPAIR DATA, Genetic epidemiology, 15(3), 1998, pp. 263-278
Citations number
46
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
15
Issue
3
Year of publication
1998
Pages
263 - 278
Database
ISI
SICI code
0741-0395(1998)15:3<263:TCHIML>2.0.ZU;2-J
Abstract
We provide a general framework for the development of model-free metho ds for the linkage analysis of multivariate phenotypic data. It is pos sible within this framework to test both for linkage of a set of pheno types to one or more markers and for the presence of structural relati ons among the phenotypes themselves. This report presents the general model, paying special attention to the assumptions that enter its form ulation, and outlines the estimation procedures that may be used. (C) 1998 Wiley-Liss, Inc.